Iron–sulphur cluster biogenesis and mitochondrial iron homeostasis
TA Rouault, WH Tong - Nature Reviews Molecular Cell Biology, 2005 - nature.com
TA Rouault, WH Tong
Nature Reviews Molecular Cell Biology, 2005•nature.comIron–sulphur clusters are important cofactors for proteins that are involved in many cellular
processes, including electron transport, enzymatic catalysis and regulation. The enzymes
that catalyse the formation of iron–sulphur clusters are widely conserved from bacteria to
humans. Recent studies in model systems and humans reveal that iron–sulphur proteins
have important roles in mitochondrial iron homeostasis and in the pathogenesis of the
human disease Friedreich ataxia.
processes, including electron transport, enzymatic catalysis and regulation. The enzymes
that catalyse the formation of iron–sulphur clusters are widely conserved from bacteria to
humans. Recent studies in model systems and humans reveal that iron–sulphur proteins
have important roles in mitochondrial iron homeostasis and in the pathogenesis of the
human disease Friedreich ataxia.
Abstract
Iron–sulphur clusters are important cofactors for proteins that are involved in many cellular processes, including electron transport, enzymatic catalysis and regulation. The enzymes that catalyse the formation of iron–sulphur clusters are widely conserved from bacteria to humans. Recent studies in model systems and humans reveal that iron–sulphur proteins have important roles in mitochondrial iron homeostasis and in the pathogenesis of the human disease Friedreich ataxia.
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