Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases

AM Musti, M Treier, D Bohmann - Science, 1997 - science.org
AM Musti, M Treier, D Bohmann
Science, 1997science.org
The proto-oncogene-encoded transcription factor c-Jun activates genes in response to a
number of inducers that act through mitogen-activated protein kinase (MAPK) signal
transduction pathways. The activation of c-Jun after phosphorylation by MAPK is
accompanied by a reduction in c-Jun ubiquitination and consequent stabilization of the
protein. These results illustrate the relevance of regulated protein degradation in the signal-
dependent control of gene expression.
The proto-oncogene-encoded transcription factor c-Jun activates genes in response to a number of inducers that act through mitogen-activated protein kinase (MAPK) signal transduction pathways. The activation of c-Jun after phosphorylation by MAPK is accompanied by a reduction in c-Jun ubiquitination and consequent stabilization of the protein. These results illustrate the relevance of regulated protein degradation in the signal-dependent control of gene expression.
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