[HTML][HTML] The Antidiabetic Agent LG100754 Sensitizes Cells to Low Concentrations of Peroxisome Proliferator-activated Receptor γ Ligands∗
BM Forman - Journal of Biological Chemistry, 2002 - ASBMB
Insulin resistance and non-insulin-dependent diabetes mellitus are major causes of
morbidity and mortality in industrialized nations. Despite the alarming rise in the prevalence
of this disorder, the initial molecular events that promote insulin resistance remain unclear.
The data presented here demonstrate that LG100754, an antidiabetic RXR ligand, defines a
novel type of nuclear receptor agonist. Surprisingly, LG100754 has minimal intrinsic
transcriptional activity, instead it enhances the potency of proliferator-activated receptor …
morbidity and mortality in industrialized nations. Despite the alarming rise in the prevalence
of this disorder, the initial molecular events that promote insulin resistance remain unclear.
The data presented here demonstrate that LG100754, an antidiabetic RXR ligand, defines a
novel type of nuclear receptor agonist. Surprisingly, LG100754 has minimal intrinsic
transcriptional activity, instead it enhances the potency of proliferator-activated receptor …