The functions of UCH-L1 and its relation to neurodegenerative diseases
R Setsuie, K Wada - Neurochemistry international, 2007 - Elsevier
Parkinson's disease (PD) and Alzheimer's disease (AD), the most common
neurodegenerative diseases, are caused by both genetic and environmental factors.
Ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) is a deubiquitinating enzyme that is
involved in the pathogenesis of both of these neurodegenerative diseases. Several
functions of UCH-L1, other than as an ubiquitin hydrolase, have been proposed; these
include acting as an ubiquitin ligase and stabilizing mono-ubiquitin. This review focuses on …
neurodegenerative diseases, are caused by both genetic and environmental factors.
Ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) is a deubiquitinating enzyme that is
involved in the pathogenesis of both of these neurodegenerative diseases. Several
functions of UCH-L1, other than as an ubiquitin hydrolase, have been proposed; these
include acting as an ubiquitin ligase and stabilizing mono-ubiquitin. This review focuses on …