[HTML][HTML] p300 interacts with the N-and C-terminal part of PPARγ2 in a ligand-independent and-dependent manner, respectively
L Gelman, G Zhou, L Fajas, E Raspé… - Journal of Biological …, 1999 - ASBMB
The nuclear peroxisome proliferator-activated receptor γ (PPARγ) activates the transcription
of multiple genes involved in intra-and extracellular lipid metabolism. Several cofactors are
crucial for the stimulation or the silencing of nuclear receptor transcriptional activities. The
two homologous cofactors p300 and CREB-binding protein (CBP) have been shown to co-
activate the ligand-dependent transcriptional activities of several nuclear receptors as well
as the ligand-independent transcriptional activity of the androgen receptor. We show here …
of multiple genes involved in intra-and extracellular lipid metabolism. Several cofactors are
crucial for the stimulation or the silencing of nuclear receptor transcriptional activities. The
two homologous cofactors p300 and CREB-binding protein (CBP) have been shown to co-
activate the ligand-dependent transcriptional activities of several nuclear receptors as well
as the ligand-independent transcriptional activity of the androgen receptor. We show here …