[HTML][HTML] Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc
Unlike normal mammalian cells, which use oxygen to generate energy, cancer cells rely on
glycolysis for energy and are therefore less dependent on oxygen. We previously observed
that the c-Myc oncogenic transcription factor regulates lactate dehydrogenase A and
induces lactate overproduction. We, therefore, sought to determine whether c-Myc controls
other genes regulating glucose metabolism. In Rat1a fibroblasts and murine livers
overexpressing c-Myc, the mRNA levels of the glucose transporter GLUT1, phosphoglucose …
glycolysis for energy and are therefore less dependent on oxygen. We previously observed
that the c-Myc oncogenic transcription factor regulates lactate dehydrogenase A and
induces lactate overproduction. We, therefore, sought to determine whether c-Myc controls
other genes regulating glucose metabolism. In Rat1a fibroblasts and murine livers
overexpressing c-Myc, the mRNA levels of the glucose transporter GLUT1, phosphoglucose …