[HTML][HTML] Mechanism of ATP-binding cassette transporter A1-mediated cellular lipid efflux to apolipoprotein AI and formation of high density lipoprotein particles
C Vedhachalam, PT Duong, M Nickel, D Nguyen… - Journal of Biological …, 2007 - ASBMB
The ATP-binding cassette transporter A1 (ABCA1) plays a critical role in the biogenesis of
high density lipoprotein (HDL) particles and in mediating cellular cholesterol efflux. The
mechanism by which ABCA1 achieves these effects is not established, despite extensive
investigation. Here, we present a model that explains the essential features, especially the
effects of ABCA1 activity in inducing apolipoprotein (apo) AI binding to cells and the
compositions of the discoidal HDL particles that are produced. The apo AI/ABCA1 reaction …
high density lipoprotein (HDL) particles and in mediating cellular cholesterol efflux. The
mechanism by which ABCA1 achieves these effects is not established, despite extensive
investigation. Here, we present a model that explains the essential features, especially the
effects of ABCA1 activity in inducing apolipoprotein (apo) AI binding to cells and the
compositions of the discoidal HDL particles that are produced. The apo AI/ABCA1 reaction …