Role of activation of the coagulation factor VIII in interaction with vWf, phospholipid, and functioning within the factor Xase complex
EL Saenko, M Shima, AG Sarafanov - Trends in cardiovascular medicine, 1999 - Elsevier
Blood coagulation factor VIII (fVIII) in its nonactivated form circulates in plasma in a complex
with von Willebrand factor (vWf). Upon activation by thrombin-or factor Xa-mediated site-
specific proteolysis, activated fVIII (fVIIIa) serves as a cofactor for factor IXa. This protein
complex assembled on a phospholipid surface (factor Xase) activates factor X. This complex
plays the key role in the intrinsic pathway of blood coagulation. We reviewed the molecular
events triggered by fVIII activation, which are required for the assembly and functioning of …
with von Willebrand factor (vWf). Upon activation by thrombin-or factor Xa-mediated site-
specific proteolysis, activated fVIII (fVIIIa) serves as a cofactor for factor IXa. This protein
complex assembled on a phospholipid surface (factor Xase) activates factor X. This complex
plays the key role in the intrinsic pathway of blood coagulation. We reviewed the molecular
events triggered by fVIII activation, which are required for the assembly and functioning of …