The M-current has been proposed as a potential target for analgesia under neuropathic pain
conditions. M-currents and/or their molecular correlates, KCNQ proteins, have been
demonstrated in key elements of the nociceptive system including spinal and dorsal root
ganglion neurons. Here we demonstrate that retigabine, a selective KCNQ channel opener,
applied at neuromatose endings modulates the excitability of axotomized fibres inhibiting
ectopic discharges. Responses to mechanical and chemical stimulation were obtained from …