Establishment of protective immunity against cerebral cryptococcosis by means of an avirulent, non melanogenic Cryptococcus neoformans strain
R Barluzzi, A Brozzetti, G Mariucci, M Tantucci… - Journal of …, 2000 - Elsevier
The opportunistic fungal pathogen, Cryptococcus neoformans, shows a marked predilection
for the central nervous system (CNS). This can be partially explained by its ability to
synthesize melanin starting from the catecholamines, highly concentrated at the CNS level.
Two cryptococcal strains, the avirulent non-melanogenic strain Sb26 and the virulent
melanogenic revertant strain Sb26Rev, were used in a murine model of intracerebral (ic)
infection, in order to evaluate their virulence and immunomodulating properties at the …
for the central nervous system (CNS). This can be partially explained by its ability to
synthesize melanin starting from the catecholamines, highly concentrated at the CNS level.
Two cryptococcal strains, the avirulent non-melanogenic strain Sb26 and the virulent
melanogenic revertant strain Sb26Rev, were used in a murine model of intracerebral (ic)
infection, in order to evaluate their virulence and immunomodulating properties at the …