CCL19 is constitutively expressed in the CNS, up-regulated in neuroinflammation, active and also inactive multiple sclerosis lesions
M Krumbholz, D Theil, F Steinmeyer, S Cepok… - Journal of …, 2007 - Elsevier
CCL19 and CCL21 bind to CCR7, which is crucial for both inducing an immune response
and establishing immunological tolerance. We report that in the normal human brain CCL19,
but not CCL21, is transcribed, and detectable as a protein in tissue lysates and in
cerebrospinal fluid. In both active and inactive multiple sclerosis (MS) lesions CCL19
transcripts were elevated. In cerebrospinal fluid from MS and OIND patients CCL19 protein
was increased. In relapsing–remitting and secondary progressive MS patients CCL19 …
and establishing immunological tolerance. We report that in the normal human brain CCL19,
but not CCL21, is transcribed, and detectable as a protein in tissue lysates and in
cerebrospinal fluid. In both active and inactive multiple sclerosis (MS) lesions CCL19
transcripts were elevated. In cerebrospinal fluid from MS and OIND patients CCL19 protein
was increased. In relapsing–remitting and secondary progressive MS patients CCL19 …