Determinants of CCL5-driven mononuclear cell migration across the blood–brain barrier. Implications for therapeutically modulating neuroinflammation
EE Ubogu, MK Callahan, BH Tucky… - Journal of …, 2006 - Elsevier
Chemokine receptors and adhesion molecules are used selectively for the transmigration of
leukocytes across the blood–brain barrier (BBB) during neuroinflammation. We established
an activated in vitro BBB (aIVBBB) using physiological concentrations of cytokines. We
studied CCL5-driven migration as a model to determine how chemokine receptors and
adhesion molecules regulate T-cell and monocyte migration across the aIVBBB. Increased
expression of CCL5 and its receptors, CCR1 and CCR5 have been described in the …
leukocytes across the blood–brain barrier (BBB) during neuroinflammation. We established
an activated in vitro BBB (aIVBBB) using physiological concentrations of cytokines. We
studied CCL5-driven migration as a model to determine how chemokine receptors and
adhesion molecules regulate T-cell and monocyte migration across the aIVBBB. Increased
expression of CCL5 and its receptors, CCR1 and CCR5 have been described in the …