Increased levels of lipid oxidation products in low density lipoproteins of patients suffering from rheumatoid arthritis
W Jira, G Spiteller, A Richter - Chemistry and physics of lipids, 1997 - Elsevier
9-Hydroxy-10, 12-octadecadienoic acid (9-HODE) and 13-hydroxy-9, 11-octadecadienoic
acid (13-HODE) are accumulated in the low density lipoproteins of patients suffering from
rheumatoid arthritis for a factor of 20–50 compared to healthy individuals of the same age.
Both acids, derived by lipid peroxidation of linoleic acid, induce the release of interleukin 1β.
The latter induces bone degression. The genesis of 9-and 13-HODE seems therefore to be
an important factor in the development and progression of rheuma; in addition 9-HODE was …
acid (13-HODE) are accumulated in the low density lipoproteins of patients suffering from
rheumatoid arthritis for a factor of 20–50 compared to healthy individuals of the same age.
Both acids, derived by lipid peroxidation of linoleic acid, induce the release of interleukin 1β.
The latter induces bone degression. The genesis of 9-and 13-HODE seems therefore to be
an important factor in the development and progression of rheuma; in addition 9-HODE was …