[HTML][HTML] Replication-selective virotherapy for cancer: biological principles, risk management and future directions
D Kirn, RL Martuza, J Zwiebel - Nature medicine, 2001 - nature.com
D Kirn, RL Martuza, J Zwiebel
Nature medicine, 2001•nature.comIn the search for novel cancer therapies that can be used in conjunction with existing
treatments, one promising area of research is the use of viral vectors and whole viruses. This
review describes the underlying biological principles and current status of the field, outlines
approaches for improving clinical effectiveness and discusses the unique safety and
regulatory issues surrounding viral therapies.
treatments, one promising area of research is the use of viral vectors and whole viruses. This
review describes the underlying biological principles and current status of the field, outlines
approaches for improving clinical effectiveness and discusses the unique safety and
regulatory issues surrounding viral therapies.
Abstract
In the search for novel cancer therapies that can be used in conjunction with existing treatments, one promising area of research is the use of viral vectors and whole viruses. This review describes the underlying biological principles and current status of the field, outlines approaches for improving clinical effectiveness and discusses the unique safety and regulatory issues surrounding viral therapies.
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