FoxP3+ T cells play critical roles in regulation of the hematolymphoid system and prevention
of autoimmunity. Many FoxP3+ T cells, generated in thymus as the result of T cell receptor
(TCR) recognition of self antigens, preferentially migrate to secondary lymphoid tissues such
as lymph nodes and spleen in a manner similar to conventional naïve T cells. FoxP3+ T cells
differentiated in the periphery acquire homing phenotype to bone marrow and nonlymphoid
tissues. Consistently, lymphoid-and nonlymphoid-tissue-homing FoxP3+ T cell subsets …