[HTML][HTML] The WD40 repeats of FANCL are required for Fanconi anemia core complex assembly
AM Gurtan, P Stuckert, AD D'Andrea - Journal of biological chemistry, 2006 - ASBMB
Fanconi anemia (FA) is an autosomal recessive disorder characterized by aplastic anemia,
cancer susceptibility, and cellular sensitivity to mitomycin C. Eight of the 11 cloned Fanconi
anemia gene products (FANCA,-B,-C,-E,-F,-G,-L, and-M) form a multisubunit nuclear
complex (FA core complex) required for monoubiquitination of a downstream FA protein,
FANCD2. FANCL, which possesses three WD40 repeats and a plant homeodomain (PHD),
is the putative E3 ubiquitin ligase subunit of the FA complex. Here, we demonstrate that the …
cancer susceptibility, and cellular sensitivity to mitomycin C. Eight of the 11 cloned Fanconi
anemia gene products (FANCA,-B,-C,-E,-F,-G,-L, and-M) form a multisubunit nuclear
complex (FA core complex) required for monoubiquitination of a downstream FA protein,
FANCD2. FANCL, which possesses three WD40 repeats and a plant homeodomain (PHD),
is the putative E3 ubiquitin ligase subunit of the FA complex. Here, we demonstrate that the …