[HTML][HTML] The Fanconi family adds a fraternal twin
M Grompe, H van de Vrugt - Developmental cell, 2007 - cell.com
Developmental cell, 2007•cell.com
The Fanconi anemia (FA) pathway plays an important role in DNA repair. In a recent issue of
Cell, Smogorzewska et al.(2007) now demonstrate that FANCD2 has a paralog, FANCI.
FANCI and FANCD2 form the" ID" complex that loads onto chromatin after DNA damage.
Like FANCD2, monoubiquitination of FANCI requires the FA core complex. Importantly,
FANCI and FANCD2 monoubiquitination is codependent, suggesting a novel mechanism in
ubiquitin conjugation.
Cell, Smogorzewska et al.(2007) now demonstrate that FANCD2 has a paralog, FANCI.
FANCI and FANCD2 form the" ID" complex that loads onto chromatin after DNA damage.
Like FANCD2, monoubiquitination of FANCI requires the FA core complex. Importantly,
FANCI and FANCD2 monoubiquitination is codependent, suggesting a novel mechanism in
ubiquitin conjugation.
The Fanconi anemia (FA) pathway plays an important role in DNA repair. In a recent issue of Cell, Smogorzewska et al. (2007) now demonstrate that FANCD2 has a paralog, FANCI. FANCI and FANCD2 form the "ID" complex that loads onto chromatin after DNA damage. Like FANCD2, monoubiquitination of FANCI requires the FA core complex. Importantly, FANCI and FANCD2 monoubiquitination is codependent, suggesting a novel mechanism in ubiquitin conjugation.
cell.com