Antiproliferative action of interferon-α requires components of T-cell-receptor signalling

EF Petricoin III, S Ito, BL Williams, S Audet, LF Stancato… - Nature, 1997 - nature.com
EF Petricoin III, S Ito, BL Williams, S Audet, LF Stancato, A Gamero, K Clouse, P Grimley…
Nature, 1997nature.com
Signal transduction through both cytokine and lymphocyte antigen receptors shares some
common pathways by which they initiate cellular responses, such as activation of mitogen-
activated protein kinase (s),. However, other signalling components appear to be uniquely
coupled to each receptor. For example, the interferon receptors transduce regulatory signals
through the JAK/STAT pathway, resulting in an inhibition of growth and of antiviral effects,
whereas this pathway apparently plays no role in T-cell-receptor (TCR)-dependent gene …
Abstract
Signal transduction through both cytokine and lymphocyte antigen receptors shares some common pathways by which they initiate cellular responses, such as activation of mitogen-activated protein kinase(s),. However, other signalling components appear to be uniquely coupled to each receptor. For example, the interferon receptors transduce regulatory signals through the JAK/STAT pathway, resulting in an inhibition of growth and of antiviral effects, whereas this pathway apparently plays no role in T-cell-receptor (TCR)-dependent gene expression,. Conversely, signal transduction through the TCR requires the tyrosine kinases Lck and ZAP-70 and the tyrosine phosphatase CD45 . Here we show that, unexpectedly, transmission of growth-inhibitory signals by interferon-α (IFN-α) in T cells requires the expression and association of CD45, Lck and ZAP-70 with the IFN-α-receptor signalling complex.
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