[HTML][HTML] Sphingosine 1-phosphate analogs as receptor antagonists
MD Davis, JJ Clemens, TL Macdonald… - Journal of Biological …, 2005 - ASBMB
Sphingosine 1-phosphate (S1P) is a lysophospholipid mediator that evokes a variety of cell
and tissue responses via a set of cell surface receptors. The recent development of S1P
receptor agonists, led by the immunomodulatory pro-drug FTY720, has revealed that S1P
signaling is an important regulator of lymphocyte trafficking. With the twin goals of
understanding structure-activity relationships of S1P ligands and developing tool
compounds to explore S1P biology, we synthesized and tested numerous S1P analogs. We …
and tissue responses via a set of cell surface receptors. The recent development of S1P
receptor agonists, led by the immunomodulatory pro-drug FTY720, has revealed that S1P
signaling is an important regulator of lymphocyte trafficking. With the twin goals of
understanding structure-activity relationships of S1P ligands and developing tool
compounds to explore S1P biology, we synthesized and tested numerous S1P analogs. We …