[HTML][HTML] Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720
ML Allende, T Sasaki, H Kawai, A Olivera, Y Mi… - Journal of Biological …, 2004 - ASBMB
Sphingosine-1-phosphate (S1P), a lipid signaling molecule that regulates many cellular
functions, is synthesized from sphingosine and ATP by the action of sphingosine kinase.
Two such kinases have been identified, SPHK1 and SPHK2. To begin to investigate the
physiological functions of sphingosine kinase and S1P signaling, we generated mice
deficient in SPHK1. Sphk1 null mice were viable, fertile, and without any obvious
abnormalities. Total SPHK activity in most Sphk1-/-tissues was substantially, but not …
functions, is synthesized from sphingosine and ATP by the action of sphingosine kinase.
Two such kinases have been identified, SPHK1 and SPHK2. To begin to investigate the
physiological functions of sphingosine kinase and S1P signaling, we generated mice
deficient in SPHK1. Sphk1 null mice were viable, fertile, and without any obvious
abnormalities. Total SPHK activity in most Sphk1-/-tissues was substantially, but not …