[HTML][HTML] Granzyme-mediated cytotoxicity does not involve the mannose 6-phosphate receptors on target cells
R Dressel, SM Raja, S Höning, T Seidler… - Journal of Biological …, 2004 - ASBMB
Cytotoxic T lymphocytes (CTL) and natural killer cells secrete granzymes to kill infected or
transformed cells. The mannose 6-phosphate receptor (Mpr) 300 on target cells has been
reported to function as receptor for secreted granzyme B. Using lymphoblasts and mouse
embryonal fibroblast lines from Mpr300 and Mpr46 knockout mice, we show here that both
receptors are not essential for CTL-induced apoptosis. Similarly, cells exposed to either
monomeric granzyme B or granzyme B-serglycin complexes readily internalize the …
transformed cells. The mannose 6-phosphate receptor (Mpr) 300 on target cells has been
reported to function as receptor for secreted granzyme B. Using lymphoblasts and mouse
embryonal fibroblast lines from Mpr300 and Mpr46 knockout mice, we show here that both
receptors are not essential for CTL-induced apoptosis. Similarly, cells exposed to either
monomeric granzyme B or granzyme B-serglycin complexes readily internalize the …