[HTML][HTML] Sirtuin 1 functionally and physically interacts with disruptor of telomeric silencing-1 to regulate α-ENaC transcription in collecting duct
D Zhang, S Li, P Cruz, BC Kone - Journal of biological chemistry, 2009 - ASBMB
Aldosterone increases renal tubular Na+ absorption in large part by increasing transcription
of the epithelial Na+ channel α-subunit (α-ENaC) expressed in the apical membrane of
collecting duct principal cells. We recently reported that a complex containing the histone
H3K79 methyltransferase disruptor of telomeric silencing-1 (Dot1) associates with and
represses the α-ENaC promoter in mouse inner medullary collecting duct mIMCD3 cells,
and that aldosterone acts to disrupt this complex and its inhibitory effects (Zhang, W., Xia, X …
of the epithelial Na+ channel α-subunit (α-ENaC) expressed in the apical membrane of
collecting duct principal cells. We recently reported that a complex containing the histone
H3K79 methyltransferase disruptor of telomeric silencing-1 (Dot1) associates with and
represses the α-ENaC promoter in mouse inner medullary collecting duct mIMCD3 cells,
and that aldosterone acts to disrupt this complex and its inhibitory effects (Zhang, W., Xia, X …