Modulation of redox-sensitive transcription factors by calorie restriction during aging
HJ Kim, KJ Jung, BP Yu, CG Cho, JS Choi… - Mechanisms of ageing …, 2002 - Elsevier
Oxidative stress is considered to be a major cause of aging and many age-related diseases.
Calorie restriction (CR) is known to retard deleterious, age-related processes. Recent
studies document that CR retards the aging process by regulating the redox environment
through its anti-oxidative properties. Among the key cellular components exquisitely
sensitive to redox status are transcriptions factors such as nuclear factor kappa B (NF-κB),
activator protein-1 (AP-1), and hypoxia inducible factor-1 (HIF-1). Based on available …
Calorie restriction (CR) is known to retard deleterious, age-related processes. Recent
studies document that CR retards the aging process by regulating the redox environment
through its anti-oxidative properties. Among the key cellular components exquisitely
sensitive to redox status are transcriptions factors such as nuclear factor kappa B (NF-κB),
activator protein-1 (AP-1), and hypoxia inducible factor-1 (HIF-1). Based on available …