Analysis of the effect of aging on the response to hypoxia by cDNA microarray

H Kim, DK Lee, JW Choi, JS Kim, SC Park… - Mechanisms of ageing …, 2003 - Elsevier
Little is known about the detail of hypoxia-responsive gene expression patterns in advanced
age, even though aging is thought to be partially associated with a decreased response to
hypoxia. In the present study, we identified several hypoxia-inducible genes and
investigated the effect of aging on hypoxic gene expression profiles using cDNA microarray
analysis of young/old human diploid fibroblasts. Of 7458 genes in the microarray, we found
that genes involved in angiogenesis, defense against oxidative stress, and transcription …