[HTML][HTML] Tiam1 overexpression potentiates heregulin-induced lymphoid enhancer factor-1/β-catenin nuclear signaling in breast cancer cells by modulating the …
L Adam, RK Vadlamudi, P McCrea, R Kumar - Journal of Biological …, 2001 - ASBMB
Heregulin-β1 (HRG) promotes motility, scattering, and invasiveness of breast cancer cells.
Tiam1, a newly identified guanine nucleotide exchange factor, has been shown to inhibit or
promote cell migration in a cell type-dependent manner. In this study, we identified Tiam1 as
a target of HRG signaling. HRG stimulation of breast cancer epithelial cells induced the
phosphorylation and redistribution of Tiam1 to the membrane ruffles and the loosening of
intercellular junctions. In addition, HRG-mediated scattering of breast epithelial cells was …
Tiam1, a newly identified guanine nucleotide exchange factor, has been shown to inhibit or
promote cell migration in a cell type-dependent manner. In this study, we identified Tiam1 as
a target of HRG signaling. HRG stimulation of breast cancer epithelial cells induced the
phosphorylation and redistribution of Tiam1 to the membrane ruffles and the loosening of
intercellular junctions. In addition, HRG-mediated scattering of breast epithelial cells was …