[HTML][HTML] A novel mechanism for regulating transforming growth factor β (TGF-β) signaling: functional modulation of type III TGF-β receptor expression through …
GC Blobe, X Liu, SJ Fang, T How, HF Lodish - Journal of Biological …, 2001 - ASBMB
Transforming growth factor β (TGF-β) mediates its biological effects through three high-
affinity cell surface receptors, the TGF-β type I, type II, and type III receptors, and the Smad
family of transcription factors. Although the functions of the type II and type I receptors are
well established, the precise role of the type III receptor in TGF-β signaling remains to be
established. While expression cloning signaling molecules downstream of TGF-β, we cloned
GIPC (GAIP-interactingprotein, C terminus), a PDZ domain-containing protein. GIPC binds a …
affinity cell surface receptors, the TGF-β type I, type II, and type III receptors, and the Smad
family of transcription factors. Although the functions of the type II and type I receptors are
well established, the precise role of the type III receptor in TGF-β signaling remains to be
established. While expression cloning signaling molecules downstream of TGF-β, we cloned
GIPC (GAIP-interactingprotein, C terminus), a PDZ domain-containing protein. GIPC binds a …