The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement
B Chang, P Casali - Immunology today, 1994 - Elsevier
The variable (V) genes of antigen-selected antibodies are known to exhibit a higher
frequency of amino acid replacement mutations in the sequences encoding the antigen-
contacting complementarity-determining regions (CDRs) than in those encoding the
'structural'framework regions (FRs). Here, Bernara Chang and Paolo Casali analyse the
impact of regional differences in the codon composition of human germline Ig VH and VL
genes on regional differences in the frequency of replacement mutations in the gene …
frequency of amino acid replacement mutations in the sequences encoding the antigen-
contacting complementarity-determining regions (CDRs) than in those encoding the
'structural'framework regions (FRs). Here, Bernara Chang and Paolo Casali analyse the
impact of regional differences in the codon composition of human germline Ig VH and VL
genes on regional differences in the frequency of replacement mutations in the gene …