[HTML][HTML] Use of a biological peptide pump to study chronic peptide hormone action in transgenic mice: direct and indirect effects of angiotensin II on the heart
JP van Kats, D Methot, P Paradis… - Journal of Biological …, 2001 - ASBMB
Angiotensin II is a peptide hormone regulator of blood pressure and fluid balance in
mammals. Evidence obtained largely in vitro has also suggested that angiotensin II has
growth-promoting effects and that it might thereby contribute to such pathological
phenomena as cardiac hypertrophy, a major risk factor for cardiovascular mortality. It has
been difficult to test for the direct growth-promoting effects of angiotensin II in vivo, however,
because of the generalized effects of the peptide on hemodynamics. To overcome this …
mammals. Evidence obtained largely in vitro has also suggested that angiotensin II has
growth-promoting effects and that it might thereby contribute to such pathological
phenomena as cardiac hypertrophy, a major risk factor for cardiovascular mortality. It has
been difficult to test for the direct growth-promoting effects of angiotensin II in vivo, however,
because of the generalized effects of the peptide on hemodynamics. To overcome this …