[HTML][HTML] Mammalian heat shock factor 1 is essential for oocyte meiosis and directly regulates Hsp90α expression
A Metchat, M Åkerfelt, C Bierkamp, V Delsinne… - Journal of Biological …, 2009 - ASBMB
Heat shock transcription factor 1 (HSF1) is the main regulator of the stress response that
triggers the transcription of several genes encoding heat shock proteins (Hsps). Hsps act as
molecular chaperones involved in protein folding, stability, and trafficking. HSF1 is highly
expressed in oocytes and Hsf1 knock-out in mice revealed that in the absence of stress this
factor plays an important role in female reproduction. We previously reported that Hsf1-/-
females produce oocytes but no viable embryos. Consequently, we asked whether oocytes …
triggers the transcription of several genes encoding heat shock proteins (Hsps). Hsps act as
molecular chaperones involved in protein folding, stability, and trafficking. HSF1 is highly
expressed in oocytes and Hsf1 knock-out in mice revealed that in the absence of stress this
factor plays an important role in female reproduction. We previously reported that Hsf1-/-
females produce oocytes but no viable embryos. Consequently, we asked whether oocytes …