[HTML][HTML] Ionomycin, Thapsigargin, Ryanodine, and Sperm Induced Ca2+ Release Increase during Meiotic Maturation of Mouse Oocytes (∗)
Fertilization of mature mouse oocytes triggered highly repetitive Ca 2+ oscillations lasting 2-
3 h. However, immature oocytes generated only two or three oscillations, which ceased
within 1 h. Development of repetitive Ca 2+ transients to sperm occurred late in oocyte
maturation and was dependent on cytoplasmic modifications that were independent of cell
cycle progression from metaphase I to metaphase II. Immature oocytes released significantly
less Ca 2+ from stores than mature oocytes in response to ionomycin and thapsigargin …
3 h. However, immature oocytes generated only two or three oscillations, which ceased
within 1 h. Development of repetitive Ca 2+ transients to sperm occurred late in oocyte
maturation and was dependent on cytoplasmic modifications that were independent of cell
cycle progression from metaphase I to metaphase II. Immature oocytes released significantly
less Ca 2+ from stores than mature oocytes in response to ionomycin and thapsigargin …