[HTML][HTML] The human herpes virus 8-encoded viral FLICE inhibitory protein physically associates with and persistently activates the IκB kinase complex

L Liu, MT Eby, N Rathore, SK Sinha, A Kumar… - Journal of Biological …, 2002 - ASBMB
The human herpesvirus 8 (HHV8, also called Kaposi's sarcoma-associated herpesvirus) has
been linked to Kaposi's sarcoma and primary effusion lymphoma (PEL) in
immunocompromised individuals. We demonstrate that PEL cell lines have a constitutively
active NF-κB pathway, which is associated with persistent phosphorylation of IκBα. To
elucidate the mechanism of NF-κB activation in PEL cell lines, we have investigated the role
of viral FLICE inhibitory protein (vFLIP) in this process. We report that stable expression of …