[HTML][HTML] Latency-associated nuclear antigen (LANA) cooperatively binds to two sites within the terminal repeat, and both sites contribute to the ability of LANA to …
AC Garber, J Hu, R Renne - Journal of Biological Chemistry, 2002 - ASBMB
The latency-associated nuclear antigen (LANA) of Kaposi's sarcoma-associated herpesvirus
is a multifunctional protein with important roles in both transcriptional regulation and
episomal maintenance. LANA is also a DNA-binding protein and has been shown to
specifically bind to a region within the terminal repeat. Here, we have performed a detailed
analysis of the DNA-binding activity of LANA and show that it binds two sites separated by
22 bp. We used electrophoretic mobility shift assay to quantitatively analyze the binding sites …
is a multifunctional protein with important roles in both transcriptional regulation and
episomal maintenance. LANA is also a DNA-binding protein and has been shown to
specifically bind to a region within the terminal repeat. Here, we have performed a detailed
analysis of the DNA-binding activity of LANA and show that it binds two sites separated by
22 bp. We used electrophoretic mobility shift assay to quantitatively analyze the binding sites …