[HTML][HTML] Maternal circulation in the first-trimester human placenta—myth or reality?
R Jaffe, E Jauniaux, J Hustin - American journal of obstetrics and …, 1997 - Elsevier
The classic theory of development of the uteroplacental and intervillous circulation
determined that maternal blood enters the intervillous space in high-pressure streams from
the early first trimester. This theory has recently been challenged and our hypothesis to be
presented is that the intervillous circulation is not fully established until the end of the first
trimester. Ex vivo studies of hysterectomy specimens have demonstrated that trophoblastic
plugs obstruct blood flow into the intervillous space in early pregnancy and only at 12 to 13 …
determined that maternal blood enters the intervillous space in high-pressure streams from
the early first trimester. This theory has recently been challenged and our hypothesis to be
presented is that the intervillous circulation is not fully established until the end of the first
trimester. Ex vivo studies of hysterectomy specimens have demonstrated that trophoblastic
plugs obstruct blood flow into the intervillous space in early pregnancy and only at 12 to 13 …