Endocannabinoid system and nitric oxide are involved in the deleterious effects of lipopolysaccharide on murine decidua

CA Vercelli, J Aisemberg, S Billi, ML Wolfson… - Placenta, 2009 - Elsevier
Endocannabinoids are an important family of lipid-signaling molecules that are widely
distributed in mammalian tissues and anandamide (AEA) was the first member identified.
The uterus contains the highest concentrations of AEA yet discovered in mammalian tissues
and this suggests that it might play a role in reproduction. Previous results from our
laboratory have shown that AEA modulated NO synthesis in rat placenta. The production of
small amounts of nitric oxide regulates various physiological reproductive processes such …