Ciliary function and Wnt signal modulation

JM Gerdes, N Katsanis - Current topics in developmental biology, 2008 - Elsevier
With the increase in complexity of morphogenetic signaling cascades over the course of
evolution and the emergence of broadly ciliated organisms, the cilium seems to have
acquired a role as regulator of paracrine signal transduction. Recently, several lines of
evidence have provided a link between basal body and ciliary proteins and Wnt signaling. In
this chapter, we will evaluate the evidence linking the basal body and cilium with the
regulation of β-catenin-dependent (canonical) and β-catenin-independent (noncanonical) …