Mice with chimeric human livers: who says supermodels have to be tall?
NM Kneteman, DF Mercer - Hepatology, 2005 - journals.lww.com
In 1990 a group of scientists led by Ralph Brinster, while developing a model of neonatal
bleeding disorders, generated a novel murine line carrying a urokinase-type plasminogen
activator transgene controlled by an albumin promoter (Alb-uPA). 1 Urokinase
overproduction (targeted to the liver by the Alb promoter) yielded pups with a bleeding
phenotype. While early perinatal mortality rates were high due to bleeding complications,
some animals survived this early period only to succumb to subacute liver failure at 2-3 …
bleeding disorders, generated a novel murine line carrying a urokinase-type plasminogen
activator transgene controlled by an albumin promoter (Alb-uPA). 1 Urokinase
overproduction (targeted to the liver by the Alb promoter) yielded pups with a bleeding
phenotype. While early perinatal mortality rates were high due to bleeding complications,
some animals survived this early period only to succumb to subacute liver failure at 2-3 …