[HTML][HTML] Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved
The insulin receptor (IR) and the insulin-like growth factor I receptor (IGF-IR) have a highly
homologous structure, but different biological effects. Insulin and IGF-I half-receptors can
heterodimerize, leading to the formation of insulin/IGF-I hybrid receptors (Hybrid-Rs) that
bind IGF-I with high affinity. As the IR exists in two isoforms (IR-A and IR-B), we evaluated
whether the assembly of the IGF-IR with either IR-A or IR-B moieties may differently affect
Hybrid-R signaling and biological role. Three different models were studied:(a) 3T3-like …
homologous structure, but different biological effects. Insulin and IGF-I half-receptors can
heterodimerize, leading to the formation of insulin/IGF-I hybrid receptors (Hybrid-Rs) that
bind IGF-I with high affinity. As the IR exists in two isoforms (IR-A and IR-B), we evaluated
whether the assembly of the IGF-IR with either IR-A or IR-B moieties may differently affect
Hybrid-R signaling and biological role. Three different models were studied:(a) 3T3-like …