[HTML][HTML] A potential role for multiple tissue kallikrein serine proteases in epidermal desquamation
CA Borgono, IP Michael, N Komatsu… - Journal of biological …, 2007 - ASBMB
Desquamation of the stratum corneum is a serine protease-dependent process. Two
members of the human tissue kallikrein (KLK) family of (chymo) tryptic-like serine proteases,
KLK5 and KLK7, are implicated in desquamation by digestion of (corneo) desmosomes and
inhibition by desquamation-related serine protease inhibitors (SPIs). However, the
epidermal localization and specificity of additional KLKs also supports a role for these
enzymes in desquamation. This study aims to delineate the probable contribution of KLK1 …
members of the human tissue kallikrein (KLK) family of (chymo) tryptic-like serine proteases,
KLK5 and KLK7, are implicated in desquamation by digestion of (corneo) desmosomes and
inhibition by desquamation-related serine protease inhibitors (SPIs). However, the
epidermal localization and specificity of additional KLKs also supports a role for these
enzymes in desquamation. This study aims to delineate the probable contribution of KLK1 …