BACKGROUND: Injection of regulatory T (Treg) cells into sensitized mice abrogates the
elicitation phase of contact hypersensitivity (CHS) reactions by blocking the adherence of
leukocytes to vascular endothelium. OBJECTIVE: We set out to analyze whether adenosine,
a suppressive factor recently described as produced by Treg cells, can account for the
suppression of the effector T-cell–endothelial cell (EC) interaction. METHODS: T cells and
ECs were cultured in the presence of adenosine, and expression of adhesion molecules …