T here is a continuous flow of capillary plasma filtrate, containing proteins and cells, from the
skin exchange vessels (venules), through the interstitial space, toward the initial lymphatics.
This process provides the skin with nutrition, as well as humoral and cellular factors for local
immune defense. Skin is confronted by a specialized set of pathogenic organisms and
environmental chemicals that represent a distinctive spectrum of antigenic specificities.'It has
a unique collection of lymphoid and dendritic cells to deal with these special demands …