Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene

LK Su, KW Kinzler, B Vogelstein, AC Preisinger… - Science, 1992 - science.org
LK Su, KW Kinzler, B Vogelstein, AC Preisinger, AR Moser, C Luongo, KA Gould, WF Dove
Science, 1992science.org
Germ-line mutations of the APC gene are responsible for familial adenomatous polyposis
(FAP), an autosomal dominantly inherited disease in humans. Patients with FAP develop
multiple benign colorectal tumors. Recently, a mouse lineage that exhibits an autosomal
dominantly inherited predisposition to multiple intestinal neoplasia (Min) was described.
Linkage analysis showed that the murine homolog of the APC gene (mApc) was tightly
linked to the Min locus. Sequence comparison of mApc between normal and Min-affected …
Germ-line mutations of the APC gene are responsible for familial adenomatous polyposis (FAP), an autosomal dominantly inherited disease in humans. Patients with FAP develop multiple benign colorectal tumors. Recently, a mouse lineage that exhibits an autosomal dominantly inherited predisposition to multiple intestinal neoplasia (Min) was described. Linkage analysis showed that the murine homolog of the APC gene (mApc) was tightly linked to the Min locus. Sequence comparison of mApc between normal and Min-affected mice identified a nonsense mutation, which cosegregated with the Min phenotype. This mutation is analogous to those found in FAP kindreds and in sporadic colorectal cancers.
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