Patterns of recurrence of glioblastoma multiforme after external irradiation followed by implant boost

PK Sneed, PH Gutin, DA Larson, MK Malec… - International Journal of …, 1994 - Elsevier
Purpose: To study patterns of recurrence in patients with focal primary glioblastoma treated
on Northern California Oncology Group protocol 6G-82-2 including surgery, focal external
beam radiotherapy (59.4–60 Gy) with oral hydroxyurea followed by temporary brain implant
with high-activity iodine-125 sources (50 Gy), and six cycles of chemotherapy with
procarbazine, lomustine, and vincristine. Methods and Materials: Serial brain imaging scans
were available for review in 25 of 34 patients with glioblastoma who underwent brain …