Discrepancies between measured changes of radiobiological hypoxic fraction and oxygen tension monitoring using two assay systems
K Sasai, JM Brown - International Journal of Radiation Oncology* Biology …, 1994 - Elsevier
Purpose: This study was conducted to assess the ability of computerized pO 2 histography to
measure changes in tumor oxygenation produced by low oxygen breathing. Methods and
Materials: Female syngeneic C3H/Km mice bearing SCC VII/St carcinomas were used in
these experiments. Changes in tumor oxygenation produced by the mice breathing 10%
oxygen were assessed with computerized pO2 histography, 3 H-misonidazole binding, and
the paired survival curve assay of radiosensitivity. Results: The hypoxic cell fraction of the …
measure changes in tumor oxygenation produced by low oxygen breathing. Methods and
Materials: Female syngeneic C3H/Km mice bearing SCC VII/St carcinomas were used in
these experiments. Changes in tumor oxygenation produced by the mice breathing 10%
oxygen were assessed with computerized pO2 histography, 3 H-misonidazole binding, and
the paired survival curve assay of radiosensitivity. Results: The hypoxic cell fraction of the …