Repopulation of mouse liver with human hepatocytes and in vivo infection with hepatitis B virus

M Dandri, MR Burda, E Török, JM Pollok, A Iwanska… - Hepatology, 2001 - Elsevier
Mice containing livers repopulated with human hepatocytes would provide excellent in vivo
models for studies on human liver diseases and hepatotropic viruses, for which no
permissive cell lines exist. Here, we report partial repopulation of the liver of
immunodeficient urokinase-type plasminogen activator (uPA)/recombinant activation gene-2
(RAG-2) mice with normal human hepatocytes isolated from the adult liver. In the
transplanted mice, the production of human albumin was demonstrated, indicating that …