[HTML][HTML] Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response
Y Wang, J Shen, N Arenzana, W Tirasophon… - Journal of Biological …, 2000 - ASBMB
ATF6 is a member of the basic-leucine zipper family of transcription factors. It contains a
transmembrane domain and is located in membranes of the endoplasmic reticulum. ATF6
has been implicated in the endoplasmic reticulum (ER) stress response pathway since it can
activate expression of GRP78 and other genes induced by the ER stress response. ER
stress appears to activate ATF6 by cleavage from the ER membrane and translocation to the
nucleus. However, direct DNA binding by ATF6 had not been demonstrated. In this report …
transmembrane domain and is located in membranes of the endoplasmic reticulum. ATF6
has been implicated in the endoplasmic reticulum (ER) stress response pathway since it can
activate expression of GRP78 and other genes induced by the ER stress response. ER
stress appears to activate ATF6 by cleavage from the ER membrane and translocation to the
nucleus. However, direct DNA binding by ATF6 had not been demonstrated. In this report …