[HTML][HTML] A splice variant of CD99 increases motility and MMP-9 expression of human breast cancer cells through the AKT-, ERK-, and JNK-dependent AP-1 activation …
HJ Byun, IK Hong, E Kim, YJ Jin, DI Jeoung… - Journal of biological …, 2006 - ASBMB
The CD99 gene encodes two distinct transmembrane proteins by alternative splicing of its
transcript. To examine the effects of two CD99 isoforms on the invasive phenotypes of breast
cancer cells, MDA-MB-231 and MCF-7 human breast cancer cell lines were stably
transfected with CD99 cDNAs encoding the major wild-type form (type I) or a minor splice
variant (type II). As a result, expression of CD99 type II, but not type I, markedly elevated the
motility, binding to fibronectin, MMP-9 expression, and invasiveness of MDA-MB-231 and …
transcript. To examine the effects of two CD99 isoforms on the invasive phenotypes of breast
cancer cells, MDA-MB-231 and MCF-7 human breast cancer cell lines were stably
transfected with CD99 cDNAs encoding the major wild-type form (type I) or a minor splice
variant (type II). As a result, expression of CD99 type II, but not type I, markedly elevated the
motility, binding to fibronectin, MMP-9 expression, and invasiveness of MDA-MB-231 and …