[HTML][HTML] Identification of p21WAF1/CIP1 as a direct target of EWS-Fli1 oncogenic fusion protein
F Nakatani, K Tanaka, R Sakimura, Y Matsumoto… - Journal of Biological …, 2003 - ASBMB
Translocation t (11; 22) is a karyotypic abnormality detected in over 90% of Ewing's family
tumors. This translocation results in the EWS-Fli1 fusion gene, which has been shown to be
a potent, single-step transforming gene. We reported previously that suppression of the EWS-
Fli1 fusion protein altered the expression of G 1 regulatory cyclins and cyclin-dependent
kinase inhibitors both at mRNA and protein levels, resulting in G 1 growth arrest in Ewing's
family tumor cell lines. These data suggest that the G 1 regulatory molecules may be targets …
tumors. This translocation results in the EWS-Fli1 fusion gene, which has been shown to be
a potent, single-step transforming gene. We reported previously that suppression of the EWS-
Fli1 fusion protein altered the expression of G 1 regulatory cyclins and cyclin-dependent
kinase inhibitors both at mRNA and protein levels, resulting in G 1 growth arrest in Ewing's
family tumor cell lines. These data suggest that the G 1 regulatory molecules may be targets …