[HTML][HTML] The insulin-like growth factor-I receptor is required for EWS/FLI-1 transformation of fibroblasts
JA Toretsky, T Kalebic, V Blakesley, D LeRoith… - Journal of Biological …, 1997 - ASBMB
Ewing's family of tumors is characterized by a well described reciprocal translocation, t (11;
22)(q24; q12), which produces a fusion protein (EWS/FLI-1) that transforms mouse
fibroblasts. The EWS/FLI-1 fusion protein has been shown to act as a potent chimeric
transcription factor. Overexpression of insulin-like growth factor-I receptor (IGF-IR) has been
implicated in many tumor models as playing a role in cell growth and tumorigenesis. In
addition, blockade of the IGF-IR inhibits the growth of Ewing's family of tumors cells …
22)(q24; q12), which produces a fusion protein (EWS/FLI-1) that transforms mouse
fibroblasts. The EWS/FLI-1 fusion protein has been shown to act as a potent chimeric
transcription factor. Overexpression of insulin-like growth factor-I receptor (IGF-IR) has been
implicated in many tumor models as playing a role in cell growth and tumorigenesis. In
addition, blockade of the IGF-IR inhibits the growth of Ewing's family of tumors cells …