[HTML][HTML] Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis
Triacylglycerols (triglycerides)(TGs) are the major storage molecules of metabolic energy
and FAs in most living organisms. Excessive accumulation of TGs, however, is associated
with human diseases, such as obesity, diabetes mellitus, and steatohepatitis. The final and
the only committed step in the biosynthesis of TGs is catalyzed by acyl-CoA: diacylglycerol
acyltransferase (DGAT) enzymes. The genes encoding two DGAT enzymes, DGAT1 and
DGAT2, were identified in the past decade, and the use of molecular tools, including mice …
and FAs in most living organisms. Excessive accumulation of TGs, however, is associated
with human diseases, such as obesity, diabetes mellitus, and steatohepatitis. The final and
the only committed step in the biosynthesis of TGs is catalyzed by acyl-CoA: diacylglycerol
acyltransferase (DGAT) enzymes. The genes encoding two DGAT enzymes, DGAT1 and
DGAT2, were identified in the past decade, and the use of molecular tools, including mice …