Oxalate is a metabolic waste product excreted by the kidney. Hyperoxaluria is a common
cause of kidney stones due to the low solubility of calcium oxalate salts. Severe
hyperoxaluria may lead to loss of renal function and systemic oxalosis. Hyperoxaluria can
be caused by genetic defects that lead to endogenous overproduction or by absorption of
excessive amounts of oxalate from the diet. This article reviews oxalate metabolism and the
clinical syndromes leading to hyperoxaluria. Nephrolithiasis is the most common chronic …